| Novak Djokovic (1) (SRB) | Jeremy Chardy (FRA) | 6-3 6-1 6-2 |
| Frances Tiafoe (USA) | Stefano Travaglia (ITA) | 7-6(5) 6-2 6-2 |
| Reilly Opelka (USA) | Yen-Hsun Lu (TPE) | 6-3 7-6(2) 6-3 |
| Taylor Harry Fritz (27) (USA) | Albert Ramos-Vinolas (ESP) | 7-6(6) 3-6 6-2 7-6(6) |
| Stan Wawrinka (17) (SUI) | Pedro Sousa (PRT) | 6-3 6-2 6-4 |
| Marton Fucsovics (HUN) | Marc Polmans (WC) () | 4-6 6-3 6-1 6-7(3) 6-3 |
| Corentin Moutet (FRA) | John Millman (AUS) | 6-4 6-7(4) 3-6 6-2 6-3 |
| Milos Raonic (14) (CAN) | Federico Coria (ARG) | 6-3 6-3 6-2 |
| Emil Ruusuvuori (FIN) | Gael Monfils (10) (FRA) | 3-6 6-4 7-5 3-6 6-3 |
| Pedro Martinez Portero (ESP) | Yoshihito Nishioka (JPN) | 6-7(3) 6-1 6-1 6-1 |
| Alexander Bublik (RUS) | Aljaz Bedene (SLO) | 6-4 7-5 5-7 6-4 |
| Dusan Lajovic (23) (SRB) | Sergiy Stakhovsky (q) (UKR) | 5-7 6-4 6-3 5-7 6-4 |
| Adrian Mannarino (32) (FRA) | Dennis Novak (AUT) | 6-2 6-4 7-6(2) |
| Miomir Kecmanovic (SRB) | Kamil Majchrzak (POL) | 6-2 6-4 6-3 |
| Maxime Cressy (q) (FRA) | Taro Daniel (LL) (JPN) | 7-6(1) 7-6(3) 6-4 |
| Alexander Zverev (6) (GER) | Marcos Giron (USA) | 6-7(8) 7-6(4) 6-3 6-2 |
| Dominic Thiem (3) (AUT) | Mikhail Kukushkin (KAZ) | 7-6(2) 6-2 6-3 |
| Dominik Koepfer () | Hugo Dellien (LL) () | 7-5 6-2 6-4 |
| Nick Kyrgios (AUS) | Frederico Ferreira Silva (q) (PRT) | 6-4 6-4 6-4 |
| Ugo Humbert (29) (FRA) | Yasutaka Uchiyama (JPN) | 6-3 6-4 6-7(3) 6-3 |
| Grigor Dimitrov (18) (BUL) | Marin Cilic (CRO) | 6-4 6-2 7-6(5) |
| Alex Bolt (WC) (AUS) | Norbert Gombos (SVK) | 6-2 6-2 4-6 6-3 |
| Jiri Vesely (CZE) | Kimmer Coppejans (q) (BEL) | 6-4 3-6 6-7(3) 6-3 6-3 |
| Pablo Carreno Busta (15) (ESP) | Kei Nishikori (JPN) | 7-5 7-6(4) 6-2 |
| Denis Shapovalov (11) (CAN) | Jannik Sinner (ITA) | 3-6 6-3 6-2 4-6 6-4 |
| Bernard Tomic (q) (AUS) | Yuichi Sugita (JPN) | 3-6 6-1 4-1 ret. |
| James Duckworth (AUS) | Damir Dzumhur (LL) (BIH) | 6-3 6-2 6-4 |
| Felix Auger Aliassime (20) (CAN) | Cedrik-Marcel Stebe (LL) (GER) | 6-2 6-4 6-2 |
| Egor Gerasimov (BLR) | Benoit Paire (25) () | 6-2 2-6 7-6(5) 7-5 |
| Aslan Karatsev (q) (RUS) | Gianluca Mager (ITA) | 6-3 6-3 6-4 |
| Alexandre Muller (LL) (FRA) | Juan Ignacio Londero (ARG) | 4-6 6-3 6-0 6-3 |
| Diego Sebastian Schwartzman (8) (ARG) | Elias Ymer (q) (SWE) | 7-6(3) 6-4 2-6 6-2 |
| Andrey Rublev (7) (RUS) | Yannick Hanfmann (GER) | 6-3 6-3 6-4 |
| Thiago Moura Monteiro () | Andrej Martin (SVK) | 7-6(6) 6-1 6-2 |
| Christopher O’Connell (WC) (AUS) | Jan-Lennard Struff (GER) | 7-6(2) 7-6(5) 6-1 |
| Lloyd Harris (RSA) | Mikael Torpegaard (LL) () | 4-6 6-3 6-2 6-2 |
| Mackenzie McDonald (USA) | Marco Cecchinato (ITA) | 3-6 6-3 6-2 6-2 |
| Borna Coric (22) (CRO) | Guido Pella (ARG) | 6-3 7-6(5) 7-5 |
